Product Description

Lub xeev - ntawm - - art AMPA receptor positive allosteric modulator (PAM)TAK-653 (CAS 1211231-11-0)tau tsim tshwj xeeb tshaj yog rau kev txiav -ntug neuroscience tshawb fawb. TAK-653 yog qhov txawv ntawm cov tiam dhau los ntawm AMPA potentiators los ntawm nws nruj tswj hwm, agonist-dependent activation, uas txhim kho tej yam ntuj tso neurotransmission yam tsis muaj overstimulating lub receptor thaum tsis muaj glutamate.

Tus kheej: 1-(2-fluorophenyl)-N-(2-oxo-1,2-dihydroquinolin-6-yl)-5-oxopyrrolidine-3-carboxamide

Purity: Ntau dua lossis sib npaug rau Ntau dua lossis sib npaug rau 99.0% (HPLC Verified)

Daim ntawv: Dawb rau tawm -dawb crystalline hmoov

Qib: Laboratory Research Qib

Muaj nuj nqi & Siv

TAK-653 lub peev xwm los hloov cov kab ke glutamatergic- lub paj hlwb txoj hauv kev excitatory tseem ceeb-yog qhov tseem ceeb ntawm txoj kev kawm.

Ntev -Term Potentiation (LTP),lub hauv paus lom neeg rau kev kawm thiab kev tshawb fawb nco, yog yooj yim los ntawm synaptic plasticity.
BDNF kev nthuav qhia: Nws tau raug pom zoo kom nce lub hlwb-Derived Neurotrophic Factor (BDNF), uas yog ib qho tseem ceeb ntawm cov protein rau neurogenesis, hauv kev tshawb fawb vivo.
Rapid-Acting Modulator:Kev tshuaj xyuas rau nws lub peev xwm ua rau muaj kev hloov pauv hauv neurobehavioral nrog qhov pib sai yam tsis muaj kev ncua uas tuaj nrog cov tshuaj tiv thaiv kev ntxhov siab.

Qhov zoo

Vim tias nws qhov kev nyab xeeb zoo tshaj plaws, TAK-653 sawv tawm hauv kev tswj hwm kev lag luam hauv Asmeskas thiab Europe:

High Safety Margin (Tsis yog-Convulsive): Lub peev xwm ua rau qaug dab peg yog qhov tsis zoo ntawm ntau lub AMPA modulators. Nyob rau hauv sib piv rau nws muaj zog kev txawj ntse- txhim kho cov txiaj ntsig, TAK-653 muaj lub qhov rais dav dav thiab muaj peev xwm ua rau me me. Risk-averse R & D cov koom haum nyiam nws vim nws "huv" tus cwj pwm.
Yam tsawg kawg nkaus Agonistic Activity: Nws zam lub "suab nrov" ntawm agonists ncaj qha los ntawm tsuas yog ua haujlwm thaum lub ntuj glutamate tam sim no.
High-kawg B2B Supply: TIANJIN YINAO muaj cov ntaub ntawv ua tiav (HPLC, NMR, LC-MS) uas txaus siab rau Western chaw kuaj tshuaj 'thiab CRO' kev tshuaj xyuas nruj.

Daim ntawv thov teb

Glutamatergic Signaling Thiab Synaptic Strength Tau Kawm Hauv Kev Tshawb Fawb Neuroscience.
Kev Tshawb Fawb Txog Kev Tsis Txaus Siab: Kev Tshawb Fawb Txog Kev Tiv Thaiv Hnub Nyoog -Txog Synapse Loss.
Kev Tshawb Fawb Txog Kev nrawm nrawm-Txoj Txoj Kev Ua Haujlwm Rau Kev Coj Tus Cwj Pwm Txog Kev Nyuaj Siab Yog Paub Raws Li Mood Modulation Studies.
Drug Discovery Scaffolds: Ib Daim Ntawv Pov Thawj Siv Hauv Kev Tsim Cov Khoom Ntshiab Neuroactive Compounds.

Lub Evolution ntawm AMPA PAMs: Los ntawm IDRA-21 rau TAK-653

Feature	Gen 1:Idra-21(Classic Foundation)	Gen 2:Sunifiram(High-Sensitivity)	Gen 3: TAK-653 (Precision Peak)
R&D Cov ntsiab lus	Ib qho classic Racetam derivative; tus qauv kub rau AMPAR desensitization inhibitors.	A piperazine-raws li Ampakine qauv paub txog nws qhov muaj zog heev.	Tsim los ntawm Takeda; ib qho chaw kho mob -qib, xaiv PAM heev.
Mechanism	Feem ntau qeeb ntawm cov txheej txheem desensitization ntawm AMPA receptor.	Ua kom muaj zog AMPA receptor txhim kho ntawm micro- koob.	Agonist{0}} nyob ntawm kev ua kom tiav; tsuas yog activates nyob rau hauv lub xub ntiag ntawm ntuj glutamate.
Kev nyab xeeb Margin	Nqaim. Kev pheej hmoo ntawm ntau dua - excitation thiab neurotoxicity ntawm koob tshuaj ntau.	Nruab nrab. High rhiab heev yuav tsum tau muaj tseeb heev kev sim koob tshuaj.	Dav dav heev. Zoo li xoom convulsive muaj peev xwm ntawm kev tshawb fawb koob tshuaj.
Tshawb nrhiav tus nqi	Cov qauv siv hauv paus rau kev tshawb fawb glutamatergic.	Qhov zoo tshaj plaws rau cov kev tshawb fawb xav tau qhov siab tshaj plaws synaptic rhiab heev thiab "potency."	Covthawj xaivrau cov tsev kawm ntawv tsom mus rau siab -kev nyab xeeb kev paub kev tshawb fawb.

Vim li cas "Qhov Kawg Version" yog TAK-653

TAK-653 hais txog qhov teeb meem tsis tu ncua hauv kev lag luam R & D: excitotoxicity.

Idra-21/Sunifiram: Lawv cov koob tshuaj- cov lus teb nkhaus feem ntau yog "Tswb-zoo li tus," uas txhais tau hais tias dhau ntawm qhov ntau npaum li cas, qhov kev pheej hmoo ntawm overstimulation nce thiab kev nyab xeeb poob qis heev.
Vim nws "Agonist{0}}dependent" mechanism, TAK-653's kev ruaj ntseg profile yog piav raws li "Broad Safety Plateau." Lub receptor overload txuas rau cov tiam dhau los tsis tshwm sim, txawm tias koob tshuaj tau nce hauv qhov kev tshawb fawb ntau.

Cov ntsiab lus tseem ceeb: TAK-653 vsIDRA-21kev ruaj ntseg profile, Sunifiram mechanism ntawm kev txiav txim, Tom ntej no -gen AMPA receptor PAMs wholesale.

Vim li cas thiaj xaiv peb?

Peb cov khoom tau ntse nkag mus rau hauv lub ntiaj teb no kev ua lag luam thiab tau dav siv los ntawm thoob ntiaj teb renowned hom nyob rau hauv cov tshuaj, kev noj qab haus huv ntxiv, tshuaj pleev ib ce, tsiaj noj khoom haus, thiab ua hauj lwm cov zaub mov industries. Raws li ib tug neeg muag khoom nrog ntau tshaj 15 xyoo ntawm kev paub, peb lub tuam txhab muaj kwv yees li 2,000 cog rho tawm. Peb tsom mus rau kev tshawb fawb thiab kev tsim kho thev naus laus zis, tuav ntau yam kev tsim khoom patents thiab tso siab rau pab pawg ntawm cov kws tshaj lij thiab cov kws tshaj lij kev lag luam los xyuas kom meej thoob ntiaj teb kev sib tw ntawm peb cov khoom raws li kev tswj xyuas zoo.