Khoom taw qhia
1 -(methylsulfonyl) spiro [dihydroindole-3,4'-piperidine](CAS Tsis yog. 178261-41-1) yog ib qho tseem ceeb ntawm cov organic nruab nrab, feem ntau yog siv hauv kev tsim tshuaj thiab kev lag luam tshuaj zoo.
Cov khoom no yog ib qho kev tshaj lij spirocyclic heterocyclic tsev thaiv. "spiro" tsim yog ib qho tseem ceeb scaffold rau qhov tseeb khi rau cov hom phiaj lom neeg nyob rau hauv niaj hnub tshuaj chemistry vim hais tias nws muaj zoo molecular txhav thiab ib tug tshwj xeeb peb -dimensional orientation.
Nyob rau hauv tshuaj chemistry, no spirocyclic molecule yog ib tug heev nrhiav- tom qab scaffold, tshwj xeeb tshaj yog nyob rau hauv lub synthesis ntawm loj hlob hormone secretagogue receptor (GHSR) agonists thiab CNS -active tshuaj. Nrog cov kev txheeb xyuas meej, TIANJIN YINAO lav qhov zoo tshaj plaws ntawm cov qauv kev ncaj ncees.
Ua kom tiav IUPAC Lub Npe: 1-methylsulfonyl-1,2-dihydrospiro[indole-3,4'-piperidine]
Cov mis mos molecular: C13H18N2O2SC13H18N2O2S
Exact Mass: 266.1089 Da (Monoisotopic)
CAS Nr .: 178261-41-1
Purity: Ntau dua lossis sib npaug rau Ntau dua lossis sib npaug rau 98% (HPLC)
Synthesis Pathway & Key Intermediates
Txhawm rau lav tias cov pab pawg methylsulfonyl tsuas yog sib koom ua ke rau indoline nitrogen, peb txoj kev tsim khoom muaj qhov tseem ceeb ntawm regioselectivity. Cov nram qab no tseem ceeb intermediates feem ntau koom nrog hauv cov synthesis:
- Intermediate A: Cov tub ntxhais tseem ceeb heterocyclic yog spiro [indoline-3,4'-piperidine].
- Lub 1'-Boc tiv thaiv tub ntxhais ntawm nruab nrab B, tert-butyl spiro[indoline-3,4'-piperidine]-1'-carboxylate, xyuas kom meej regioselective sulfonylation ntawm N1 txoj hauj lwm.
- Cov tshuaj tiv thaiv ua ntej kev tiv thaiv zaum kawg yog Intermediate C: 1'-Boc-1-(methylsulfonyl)spiro[indoline-3,4'-piperidine].
TIANJIN YINAO tau txais yam tsawg kawg nkaus ntawm cov khoom siv hlau nplaum thiab txhim kho crystalline ruaj khov los ntawm kev tswj cov kauj ruam hauv nruab nrab.
R & D Client Focus: Custom Synthesis & Scalability
Peb paub txog cov kev xav tau tshwj xeeb ntawm CROs thiab cov chaw tshawb fawb tshuaj. Peb muab cov kev pabcuam customized los pab koj txoj kev tshawb nrhiav tshuaj yeeb tshuaj ntxiv rau cov khoom siv catalog:
- Kev Cai Synthesis: Nyob ntawm koj qhov tshwj xeeb SAR (Structure-Kev Sib Raug Zoo) xav tau, peb tuaj yeem hloov pauv spiro core lossis sulfonyl tail (xws li ethylsulfonyl lossis phenylsulfonyl).
- Salt Form Optimization: Rau qhov zoo tshaj plaws solubility nyob rau hauv ntau yam kev ntsuam xyuas buffers, nws yog muaj raws li dawb Base los yog Hydrochloride (HCl) ntsev.
- Hauv -Tshuag thiab xa khoom sai thoob ntiaj teb: ntim ruaj ntseg rau kev thauj mus los ntawm cov tshuaj ilv.
Muaj nuj nqi
Raws li cov tshuaj nruab nrab: Cov tshuaj no yog ib qho tseem ceeb ntawm cov synthesis ntawm MK-677, uas yog siv los kawm txog kev tso tawm cov tshuaj hormones loj hlob (HGH) thiab tej zaum yuav muaj feem cuam tshuam rau cov leeg nqaij, rog metabolism thiab pob txha noj qab haus huv.
Daim ntawv thov
1. Nyob rau hauv lub teb ntawm kws tshuaj synthesis:
Nws ua haujlwm raws li amide daim ntawv cog lus condensing tus neeg sawv cev, tus neeg saib xyuas kev tiv thaiv, thiab cov protein cross -txuas tus neeg sawv cev rau cov tsis yog -natural amino acids thiab antibody- tshuaj conjugates.
Nws yog ib qho hluavtaws nruab nrab rau MK677 (ib qho kev loj hlob hormone- tso peptide analog).
2. Nyob rau hauv cov tshuaj zoo:
Siv rau hauv kev tshawb fawb thiab kev tsim kho thiab tsim cov tshuaj tua kab thiab tshuaj intermediates, uas muaj cov txheej txheem xws li fluorination thiab coupling tshua.
3. Lwm yam kev siv:
Siv raws li tus qauv siv impurity rau kev ntsuam xyuas purity, kev tswj kom zoo, thiab kev saib xyuas ib puag ncig hauv kev tsim tshuaj.
OEM & ODM
Peb ua tau raws li peb cov neeg siv khoom xav tau nrog cov khoom lag luam hloov tau yooj yim, muab ntau hom tshuaj, suav nrog cov hmoov sib xyaw, granules, mos thiab tawv capsules, ntsiav tshuaj, thiab gummies, nrog rau kev xaiv ntim nruab nrab. Tag nrho peb cov khoom qhia txog peb txoj kev nrhiav cov organic, nyab xeeb, thiab ntuj zoo.
Delivery & Shipping & Pob
International Express-- Fedex/DHL/UPS, huab cua shipping thiab hiav txwv shipping, ob-clearance kev cai.
|
Ntim Cov Lus Qhia |
10g / Hnab, 1Kg / hnab / 25kg / Nruas, Raws li koj xav tau |
|
Chaw nres nkoj |
Tuam Tshoj qhov chaw nres nkoj loj |
Vim li cas thiaj xaiv peb?
1. Ntau tshaj 15 Xyoo Botanical Extract Supplier, thiab nyob ib ncig ntawm 2000 yam khoom!
2. tsom rau kev txhim kho cov khoom xyaw cog rau ntau tshaj 15 xyoo thiab muaj ntau lub teb chaws invention patents.
3. International certification system: ISO9001, ISO22000, IP (tsis yog GMO), Jewish, halal, organic thiab lwm yam ntawv pov thawj.
4. Cov kws tshaj lij thiab paub txog r&d pab pawg: cov kws tshaj lij los ntawm cov tsev kawm qib siab nto moo thiab cov kws tshaj lij nrog ntau xyoo ntawm kev ua haujlwm hauv kev lag luam no.
5. Muab cov khoom sib txawv: cov khoom siv tau siv rau txhua lub npe thoob ntiaj teb hauv cov tshuaj, cov khoom noj khoom haus, tshuaj pleev ib ce, khoom noj tsiaj thiab khoom noj khoom haus.
FAQ
Q: Kuv puas tuaj yeem kuaj xyuas cov khoom ua ntej yuav khoom ntau?
A: Tau kawg. Koj tuaj yeem yuav cov qauv sim ntawm qee cov khoom. Tom qab koj txaus siab rau qhov kev xeem thiab tso ib qho kev txiav txim ntau, peb yuav rov qab koj cov nqi coj mus kuaj.
Q: Kuv tuaj yeem ua kom cov khoom ua tau raws li kuv xav tau?
A: Peb muab cov qauv kev pabcuam rau koj qhov kev ntsuam xyuas. Yog tias koj muaj kev xav tau tshwj xeeb, peb tuaj yeem nrhiav cov khoom tsim nyog rau koj hauv kev lag luam hauv zos.
Q: Koj puas muab cov qauv? Txoj cai yog dab tsi?
A: Yog, peb muab cov qauv luv nqi rau ntau yam khoom. Thaum koj dhau qhov kev xeem thiab tso ib qho kev txiav txim, tus nqi coj mus kuaj yuav raug rov qab rau hauv qhov kev txiav txim tom ntej.
Q: Yuav ua li cas yog tias kuv muaj cov khoom tshwj xeeb?
A: Thov qhia rau peb paub koj cov kev xav tau ntxaws, thiab peb yuav siv peb cov peev txheej hauv zos los sim peb qhov zoo tshaj plaws los nrhiav cov khoom uas ua tau raws li koj cov kev xav tau.
Q: Kuv tuaj yeem soj ntsuam cov khoom ua ntej muab qhov kev txiav txim ntau npaum li cas?
A: Peb pom zoo kom yuav cov qauv los xyuas qhov zoo ntawm koj tus kheej. Cov nqi coj mus kuaj tau zoo dua, thiab cov nqi coj mus kuaj tau rov qab rau kev txiav txim ntau. Q: Kuv tsis paub meej tias cov khoom tsim nyog, kuv yuav ua li cas?
Cim npe nrov: 1-methylsulfonyl-1,2-dihydrospiro[indole-3,4'-piperidine, Tuam Tshoj 1-methylsulfonyl-1,2-dihydrospiro[indole-3,4'-piperidine Hoobkas
